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OBJECTIVE:To observe therapeutic efficacy and safety of prucalopride in the treatment of chronic constipation (CC). METHODS:Totally of 100 CC patients were selected from anorectal department of our hospital during Jun. 2016-Jan. 2017, and then divided into control group and observation group according to random number table,with 50 cases in each group. Control group was given Mosapride citrate tablets 5 mg +Lactulose oral solution 10 mL orally,3 times a day. Observation group was given Prucalopride succinate tablets 2 mg orally,once a day. Both groups were treated for consecutive 4 weeks. Clinical efficacies of 2 groups were observed,and the levels of serum inflammatory factors(IL-6,TNF-α,IFN-γ)and colonic transit time(total colonic transit time,left colonic transit time,right colonic transit time,rectosigmoid colonic transit time)were observed before and after treatment. The occurrence of defecation disorders and ADR were recorded. RESULTS:None of patient in 2 groups was cured. Total response rate of observation group was 94.00%,which was significantly higher than 78.00% of control group,with statistical significance (P＜0.05). Before treatment,there was no statistical significance in the levels of serum inflammatory factors or colonic transit time (P＞0.05). After treatment,the levels of IL-6 and IFN-γ in control group,the levels of IL-6,TNF-α and IFN-γ in observation group were decreased significantly,and the levels of IL-6,TNF-α and IFN-γ in observation group were significantly lower than those of control group;the colonic transit time in 2 groups was shortened significantly,and observation group was significantly shorter than control group,with statistical significance (P＜0.05). After treatment,the incidence of defecation,incomplete emptying,sense of obstruction and sense of rectal tenesmus in observation group were significantly lower than control group,with statistical significance(P＜0.05). There was no statistical significance in the incidence of sense of rectal tenesmus after treatment or ADR between 2 groups (P＞0.05). CONCLUSIONS:Compared with traditional plan of mosapride combined with lactulose,prucalopride can more effectively reduce the levels of serum inflammatory factors,shorten colonic transit time,reduce the occurrence of defecation disorders as defecation and incomplete emptying,with equivalent safety.
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Objective To investigate the expression and the significance of AQP2 in the kidneys of septic rats. Methods Sixty-four Wistar rats of 6 weeks were randomly divided into two groups: sham group and the septic model group. Septic models were made by cecum ligation perforation (CLP). Fach group was divided into 3-hour,6-hour,12-hour and 24-hour subgroups,with 8 rats in each. The urine,blood and kidney sampies were collected. The urine volume ,urine osmotic pressure and renal function were observed. The expressions of AQP2 protein in rats' kidneys were determined by using immunohistochemical method and the expressions of AQP2 mRNA with real-time PCR. The pathological changes of the kidneys were observed under light microscopy. Results After CLP,urea volume of Wistar rats in septic model group decreased and urine osmotic pressure increased at 3 hours; urea volume gradually increased and urine osmotic pressure decreased at 6 hours; Serum Cr and urea nitrogen began to increase at 6 hours and reached the peak at 24 hours. The longer the time lasted after CLP,the more serious the injury of kidney became,which was mainly manifested as that the space between the epithelial cells of the tubular wall disappeared,nucleus disappeared,glomerular loops fused,and cell structure was unclear. Renal mesenchymal was infiltrated with inflammatory cells. AQP2 mRNA expression increased at 3 hours,decreased at 12 hours and 24 hours ,AQP2 protein expression decreased at 12 hours,with the lowest at 24 hours,which were significantly different from those of the sham groups(P<0.05). Conclusion AQP2 may regulate the water metabolism of septic rats' kidney. The decreased AQP2 protein expression is one of the main pathological mechanisms that results in dysfunction of urine concentration in sepsis.
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Objective To evaluate the surgical technique in ventricular septal defect(VSD)associated with aortic valve insufficiency(AI)patients.Methods 115 VSD patients associated with AI were retrospectively analyzed.96 patients belong subarterial to VSD,membranous defect in 19 cases.Moderate hypothermia circulatory arrest in all cases.Direct closure of the VSD was undertaken in 16 cases and other cases repaired with patches.Aortic valvuloplasty in 92 cases.and 5 patients underwent aortic valve replacement.The other 18 cases were directly repaired the VSD with patches.Results The results of surgical treatment is satisfactory.In the 4 months to 2 years follow up,10 patients died,NYHA cardic function 72 cases is Ⅰ,31 is Ⅱ and 2 is Ⅲ.Conclusion Early and concomitant surgical treatment ventricular septal defect associated with aortic valve insufficiency can obtain an ideal results.